CalRexin®:488 recognises and binds an epitope within the N-terminal domain that is common to both C1a and C1b isoforms of the human calcitonin receptor, a membrane protein with seven transmembrane domains that is coupled to G protein messenger systems. The calcitonin receptor has been identified in a broad range of tissues throughout the life-cycle of an organism as well as in diseased, stressed and damaged tissues. CalRexin®:488 is accululated into live and dying apoptotic cells and therefore is a suitable marker for apoptosis.
CalRexin® imaging reagents (antibody:fluorophores) can be readily incorporated into standard workflows, provide exceptional image clarity and produce high-fidelity data.
