CalRexin™:pHrodo™ Red is a first-in-class imaging reagent that identifies a novel marker of autophagy, namely activated calcitonin receptor. CalRexin™:pHrodo™ Red resists photobleaching and is extremely stable, properties that are essential for high throughput/content imaging of live cells over 24 hours at multiple timepoints. Unlike alternatives, CalRexin™:pHrodo™ Red passes through sequential structures of the autophagy pathway from early endosomes to autolysosomes where it fluoresces brightly in the low pH environment, illuminating multiple components of the autophagic process, in real time.
CalRexin™:pHrodo™ Red provides exceptional, high-fidelity data and is utilised for primary screening of autophagy-modulating compounds from small molecule libraries on high throughput/content platforms, invaluable for drug discovery.
